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Androgenic deficiency

Androgenic deficiency is a syndrome of an androgenodefitsit, insufficiency of testosterone (male sex hormone) in the man's organism. At teenage age it is shown by a delay of puberty and lack of secondary sexual characteristics: pilosis and a constitution on men's type, growth and development of genitals. At mature age causes decrease in sexual desire, erection, reduction of growth of hair in androgenozavisimy zones (on a face, in axillary area, on a pubis), increase in mammary glands. Leads to frustration of sexual life, infertility, personal psychological injuries.

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    Androgenic deficiency

    Androgenic deficiency is a syndrome of an androgenodefitsit, insufficiency of testosterone (male sex hormone) in the man's organism. At teenage age it is shown by a delay of puberty and lack of secondary sexual characteristics: pilosis and a constitution on men's type, growth and development of genitals. At mature age causes decrease in sexual desire, erection, reduction of growth of hair in androgenozavisimy zones (on a face, in axillary area, on a pubis), increase in mammary glands. Leads to frustration of sexual life, infertility, personal psychological injuries.

    Age androgenic deficiency is caused by insufficient quantity of androgens in the man's organism. This state is natural age change, and its first symptoms begin to be shown after 50 years, early androgenic deficiency and symptoms of presenilation are shown in 40-45 years. Androgenic insufficiency arises because of reduction of production of testosterone that affects all bodies and systems.

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    Reasons of androgenic deficiency

    Testosterone is the main men's hormone. He is responsible for formation of men's type of behavior and secondary sexual characteristics (growth of hair in the person, voice coarsening). Growth and development of genitals, an increase of muscle bulk, an erection are impossible without testosterone. Fatty cellulose at men is distributed at all not as at women; the spermatogenesis and development of a skeleton in men's type too completely depend on testosterone level in an organism.

    The hypophysis and hypothalamus produce hormones thanks to which testosterone is produced in testicles by cages of Leydinga. Both of these processes are interdependent and are regulated depending on need and from percentage concentration of each hormone. All testosterone is in blood in active and inactive fractions; the hormone which is in active fractions is responsible for the main effects of testosterone.

    The exact reason of androgenic aging is not known, but from all theories which the andrology has today, are the most probable a little. Age atherosclerotic changes in an organism lead to decrease in blood supply in testicles that influences the size and a condition of cages of Leydinga – they become less active. According to the same theory in certain time there comes apoptosis of cages of Leydinga, that is their programmed death.

    In a hypothalamus and a hypophysis with age there are also dystrophic and sclerous changes that leads to violations of regulation of process of production of testosterone. The theory that hereditary predisposition can play the main role in development of early androgenic deficiency is confirmed by the fact that activity of gormonprodutsiruyushchy fabric is genetically caused.

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    Manifestations of androgenic deficiency

    Physiological aging because of decrease in level of testosterone in blood is shown first of all from reproductive system: sexual desire (libido) decreases, the weak erection and lack of an ejaculation after sexual intercourse is possible, at some men the orgasm becomes less bright. All this leads to physiological age infertility if androgenic deficiency is not premature.

    From other bodies and systems degree of expressiveness of symptoms depends on gipogonadizm degree. Most of men has vegeto-vascular frustration: the fluctuations of arterial pressure, inflows, feeling of shortage of air, dizziness and causeless reddenings of skin of a neck and the top half of a breast which are not connected with work of adrenal glands.

    Also psychoemotional violations accrue that is shown by bystry fatigue, sleep disorders, irritability and depressions. At men the volume of muscle bulk decreases, sometimes there is its replacement on fatty, at the same time fatty tissue is laid everywhere, and not just in a hypodermic. At some men in sizes mammary glands slightly increase, and growth of hair in a face decreases. More serious manifestation of a gipogonadizm is decrease in density of a bone tissue (osteoporosis) that can become the reason of frequent changes.

    Decrease in testosterone in blood increases probability of oncological diseases of a prostate gland, probability of developing of diabetes, and also leads to progressing of atherosclerosis of vessels with high risk of a stroke of vessels of a brain and a myocardial infarction.

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    Diagnostics of androgenic deficiency

    Complaints of the patient, feature in appearance and definition of concentration of testosterone are the main diagnostic criteria. Questionnaires by means of which it is much simpler to carry out assessment of complaints of the patient besides and are more exact as the patient can not speak aloud about the problems. The questionnaire of AMS defines expressiveness of symptomatology in points, but it is in addition necessary to undergo laboratory inspection to reveal the level of androgenic deficiency.

    The laboratory investigates blood serum on the content of the general testosterone and biologically active testosterone. Will carry out the general and biochemical blood test, and will also define amount of the globulin, connecting sexual steroids (G,CSS).

    All men who have a probability of androgenic deficiency need also to undergo inspection of a bone tissue on density (densitometry) and other researches which exact list will be defined by the treating andrologist.

    Blood sampling for definition in serum of the main androgen is made in the morning and on an empty stomach as in the morning its concentration is maximum. In general testosterone in an organism of the man can be in three states, most of all testosterone, connected with albumine and globulins of serum of blood (98-99%) and free testosterone is the share of the remained 1-2%. Communication with albumine unstable therefore hormone is partially active, globulin is connected with testosterone completely therefore biological activity of hormone is suppressed completely. Free active testosterone regulates above the designated functions and determine degree of androgenic deficiency by its concentration.

    Normal indicator of the general testosterone in blood serum not less 12th nmol/l, at the same time right after obtaining results it is possible to tell about compliance of the preliminary diagnosis and reality. But in certain cases the level of the general testosterone within norm, and the content of free hormone is reduced because of its excess linkng with proteins of blood. Then resort to a research of amount of free testosterone in blood serum.

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    Treatment of androgenic deficiency

    The main method of correction of androgenic deficiency is replacement therapy with use of various medicines of testosterone. Sometimes resort to stimulation of production of own testosterone by means of a horionichesky gonadotrophin.

    Replacement therapy is carried out only after an exception of oncological diseases of a prostate gland. Therefore it is important to undergo early laboratory diagnostics on achievement of 40-45 years. As the lack of testosterone increases probability of emergence of a carcinoma of a prostate gland, and the begun replacement therapy only worsens a condition of the patient though at the normal level of testosterone in blood serum the probability of development of a carcinoma of a prostate gland is several times lower. To exclude prostate gland oncological diseases in laboratory determine the level of a prostatospetsifichesky anti-gene, and if necessary conduct more detailed examination on existence of cancer cells.

    Replaceable medicines need to be accepted for life as ovaries do not produce testosterone any more, patients need to carry out periodically control of a condition of a prostate gland and to determine the level of a prostatospetsifichesky anti-gene.

    Efficiency of treatment becomes noticeable after accumulation in an organism of the necessary concentration of testosterone and elimination of manifestations of its shortcomings. At the same time replacement therapy is completely safe, has a minimum of side effects and allows men especially with premature androgenic deficiency to lead a habitual life and to keep activity.

    Ways of introduction of testosterone to a human body a little. There are plasters, creams or gels – in this case testosterone arrives transdermalno, hypodermic implants are medicines of the prolonged action that is very convenient as there is no need to monitor daily acceptance of testosterone. Classical forms are the tableted forms for oral administration and oil solutions for intramuscular injections.

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    Androgenic deficiency - treatment should be carried out only under the supervision of a doctor. Self-treatment is unacceptable!!!

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