Papillomas a century – the opukholevidny new growths on skin of a century resulting from infection with a virus of papilloma of the person. Usually papillomas are shown only by cosmetic defect, at some localizations pains, feeling of a foreign matter and other symptoms are possible. For diagnostics use a viziometriya, a tonometriya, refractometry, computer perimetry, biomicroscopy by means of a slot-hole lamp. From additional methods apply KT and a biopsy with the subsequent histology of material. Treatment of papilloma a century – removal of a tumor by means of chemical or physical methods of destruction. Purpose of antiviral medicines is obligatory.
Papillomas are a century the tumors of an integumentary epithelium of skin of the additional device of an eye with various degree of a dysplasia caused by a virus of papilloma of the person. Most often papillomas are a century benign tumors, the malignization is observed seldom. 60–65% of all new growths fall a century to the share of such neoplaziya. Most often (3,5 cases on 100 000 population) this pathology occurs at the persons living in ekvatorialno the located countries. In Australia prevalence makes 1,9 cases on 100 000 population. In the countries with temperate and subarctic climate the disease is diagnosed less often. The age category of patients – is more senior than 30 years, average age of patients fluctuates in the range of 45-60 years. Women are ill one and a half times more often than men.
Etiology and pathogenesis of formation of papilloma century
The leading etiologichesky factor provoking development of papilloma of a century is infection with the virus of papilloma of the person (VPP). There are more than 100 various types of a papillomavirus. The virus of papilloma of the person is tropny to skin epidermis, is transmitted in direct contact with the infected epithelium (contact and household is most often observed, the sexual way of transfer is more rare). Besides, it is capable to be given from mother to a fruit. It is considered that in a basal layer there are cages, sensitive to a papillomavirus, and enough single particles of a virus to stimulate development of papilloma a century. VPCh is an obligate intracellular parasite who usually is present at an episomalny form, i.e. is in cage cytoplasm. However at a reproduction it can migrate in a kernel (integration).
Integration approach (formation of papilloma a century) is possible even in 20 years from the beginning of infection, time of development of a disease is defined not only by a virus, but also existence of hereditary predisposition of the patient in combination with other factors. Even being in cytoplasm, the virus is capable to make the intact virus particles. At this stage the infection often asymptomatically, is high-contagious, can easily extend to other fabrics and bodies and to cause formation of papillomas of a century.
Processes of replication of a virus, assembly of virus particles and their release of a cage are completely not established. In one cage the virus can exist at the same time both in a kernel, and in cytoplasm. At hit of a virus in the owner's organism his cytoplasmatic replication begins after penetration into cages of a basal layer of skin. In an orogovevayushchy layer active allocation of mature virus particles from cages is observed. These sites of skin are dangerous concerning contact infection. Refer genetic predisposition, immunological and hormonal violations to the factors promoting development of papilloma a century (diabetes, hyper - or a hypothyroidism, a menopause), pregnancy, avitaminosis, sunbed frequentation, oncological diseases, smoking, alcohol intake.
Papilloma symptoms century
The clinical picture of papilloma depends a century on localization and features of growth of education. The size, color, a form and the nature of growth can strongly vary. Most often papillomas are localized on a lower eyelid and do not influence visual acuity. Represent characteristic ekzofitny formations of grayish-yellow color with sosochkovy growths on a surface. In the center there is a vascular loop. Usually proceed asymptomatically, the patient the ophthalmologist at emergence of the obvious cosmetic defect caused by increase in papilloma of a century. At emergence of a new growth in ciliary edge or on border with a conjunctiva of the patient can show complaints to the expressed pain syndrome, feeling of a foreign matter, , hyperaemia, decrease in sight. When blinking there is a defeat of a cornea an uneven surface of papilloma of a century, as leads to emergence of these symptoms.
Complications arise at localization of papilloma at ciliary edge a century, in intermarginalny space, in the field of an internal corner of an eye, and also at distribution of a new growth on a conjunctiva. Are characterized by development of chronic slow conjunctivitis, blefarit, cornea pomutneniye. Can become a cause of infringement of growth of eyelashes that leads to cornea microinjuries with development of a keratit. Formation of an ektropion causes developing of an erosion and ulcer of a cornea, violation of visual functions, up to an eyeball atrophy. Besides, there is always a risk of a malignization of papilloma of a century.
Diagnostics and treatment of papilloma century
Diagnosis of papilloma begins a century with poll and visual survey of the patient by the ophthalmologist. Then the doctor uses standard methods of inspection: a viziometriya, a tonometriya, refractometry, computer perimetry, biomicroscopy by means of a slot-hole lamp. From additional methods if necessary the optical coherent tomography or a computer tomography (it is appointed at multiple papillomas of various localizations) is applied, capture of material on a biopsy (by means of a print, scrape or a cut) with the subsequent histologic research is carried out. In some cases consultation of the dermatologist is necessary.
To treatment of papilloma the century is applied by chemical or physical techniques of destruction of a new growth. At the same time appoint antiviral medicines with immunomodulatory activity. Refer removal of papilloma of a century by means of electrothermic coagulation to physical destructive methods, laser therapy, cryotherapy (destruction of a new growth by means of liquid nitrogen). The chemical method is based on application of various keratolitichesky means. The choice of option of treatment depends on localization and prevalence of a new growth, age of the patient. The forecast is more often favorable.
Prevention of papilloma century
Preventive actions are directed to decrease in risk of infection with a virus of papilloma of the person. Obligatory use of condoms at casual sexual contacts is recommended. In case of identification of symptoms of the VPCh-infection inspection of all sexual partners of the patient and purpose of adequate treatment is required. For reduction of risk of formation of papilloma a century it is necessary to hold events for immunity maintenance, not to touch eyes dirty hands, to lead a healthy lifestyle, to avoid reexhaustions and to actively play sports. The refusal of visit of a sunbed considerably reduces risk of developing of papilloma a century.