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Vegetiruyushchy puzyrchatka

Vegetiruyushchy puzyrchatka — one of clinical forms of a puzyrchatka which is characterized by formation of small growths (vegetations) at the bottom of an erosion after opening of a bubble. The process arrangement in skin folds and in the field of natural openings of an organism belongs to features of a disease. The Vegetiruyushchy puzyrchatka is an autoimmune disease at which because of violation in immune system there is a development of antibodies on own cells of epidermis.

Vegetiruyushchy puzyrchatka

Vegetiruyushchy puzyrchatka — one of clinical forms of a puzyrchatka which is characterized by formation of small growths (vegetations) at the bottom of an erosion after opening of a bubble. The process arrangement in skin folds and in the field of natural openings of an organism belongs to features of a disease. The Vegetiruyushchy puzyrchatka is an autoimmune disease at which because of violation in immune system there is a development of antibodies on own cells of epidermis.

Symptoms of a vegetiruyushchy puzyrchatka

The disease begins with sudden emergence on mucous a mouth of bubbles with serous and hemorrhagic liquid. Along with rashes in an oral cavity or after a while after them bubbles appear pleated skin (between buttocks, in axillary hollows, in inguinal folds, under mammary glands, behind ears), around a navel and at natural openings in places of transition of a mucous membrane to skin.

Bubbles at a vegetiruyushchy puzyrchatka have a flabby cover and are quickly enough opened with formation of erosion. At the bottom of erosion formation of the bright red papillomatozny growths appearing in 4-7 days after opening of a bubble is characteristic. Erosion increase in sizes and can merge, forming the center of 10-15 cm in size in the diameter. Separated the fetid putrefactive smell has them. Erosion are followed by the pain syndrome and burning sensation expressed to such an extent that the patient cannot actively move.

Further development of process at a vegetiruyushchy puzyrchatka leads to a strong kakheksiya of the patient. At efficiency of the carried-out treatment there is a flattening of vegetations, dehumidification and healing of erosion to formation of pigmentary spots.

Diagnostics of a vegetiruyushchy puzyrchatka

The diagnosis can be made on the basis of clinical symptoms and characteristic localization of process. Nikolsky's symptom, specific to a puzyrchatka (an otsloyka of epidermis at easy mechanical impact on skin) at a vegetiruyushchy puzyrchatka is observed only near the defeat center. Only at generalization of a disease in a terminal stage it as at a vulgar puzyrchatka, comes to light also on healthy sites of skin.

The microscopic research of dabs prints taken from a surface of erosion finds existence of akantolitichesky cages. However they are not strictly specific to a puzyrchatka as come to light also at chicken pox, herpes and other diseases.

The histologic research at a vegetiruyushchy puzyrchatka reveals existence in epidermis of cavities and horizontal cracks. Immunological researches of histologic material allow to confirm the autoimmune nature of a disease. It is the reaction of direct immunofluorescence (REEF) finding the congestions IgG in spaces between cells of epidermis, and the reaction of indirect immunofluorescence revealing a high caption autoantitet to intercellular connections — desmosomes.

Treatment of a vegetiruyushchy puzyrchatka

Treatment is carried out by corticosteroids: Prednisolonum, , dexamethasone, , etc. Therapy of a vegetiruyushchy puzyrchatka is begun with high doses. At approach of effect of treatment the dose can be reduced, however the full refusal of glucocorticoids leads to renewal of a disease. Therefore therapy is carried out even against the background of the complications arising from it.

If the vegetiruyushchy puzyrchatka has a heavy current, then in her treatment apply cytostatic medicines: , methotrexate or .

Forecast of a vegetiruyushchy puzyrchatka

The forecast, as well as at any form of a puzyrchatka, adverse. Patients perish from a kakheksiya at generalization of process and from secondary infectious complications with development of sepsis. Long therapy by corticosteroids increases probability of infection and leads to developing of endocrine pathology, gastrointestinal diseases, vascular and neurologic disorders.

Vegetiruyushchy puzyrchatka - treatment should be carried out only under the supervision of a doctor. Self-treatment is unacceptable!!!

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